A positive effect on memory, mood & energy
Pregnenolone is the precursor (building-block) for all other steroid hormones. It is converted directly into DHEA and/or progesterone. DHEA converts to testosterone and estrogens; progesterone converts to estrogens, cortisol, and aldosterone. It is this succession of conversions that makes human life possible. Without pregnenolone, there can be no human steroid hormone production.
Made from cholesterol, pregnenolone is a natural steroid hormone produced primarily in the adrenal glands, but in smaller amounts by many other organs and tissues of the human body, including liver, brain, skin, gonads, and even the retina of the eye.
Like many health-promoting hormones, levels of pregnenolone drop with age. Although the data are not as abundant or definitive for pregnenolone as they are for DHEA, Dr. Eugene Roberts, a pioneer in hormone research, believes that the age-related drop in pregnenolone is as dramatic as the drop in DHEA. At 75, our bodies typically make 60 percent less pregnenolone than at age 35. This is a point of great concern, considering pregnenolone’s numerous protective, health-promoting properties.
Energizing, anti-stress benefits
Some of the earliest investigations of pregnenolone’s many benefits showed it to be an energizing, anti-stress biochemical. During the 1940s, Drs. Pincus and Hoagland gave 50-100mg/day of pregnenolone to various types of factory workers. The factory workers noted improved production rates while taking pregnenolone. They felt less fatigued, better able to cope with their jobs and experienced an enhanced sense of happiness and well-being.
Mood elevation
Pregnenolone is known to modulate at least two key nerve receptor systems in the brain: NMDA receptors and GABA receptors. NMDA receptors, which weaken with age, are involved in learning, memory, and alertness. Pregnenolone enhances NMDA receptor function. GABA receptors promote relaxation, mental slowing, sedation and sleep. Benzodiazepine drugs (Valium, Librium, Xanax, etc.) activate GABA receptors, while pregnenolone inhibits GABA receptors. Thus, too little NMDA activity combined with excessive GABA activity would tend to promote mental sluggishness and depression. Since pregnenolone raises NMDA activity and lowers excessive GABA activity, pregnenolone seems to be a natural antidepressant. Indeed a recent study of 27 depressed patients found that their cerebrospinal fluid (which circulates through the brain and spinal cord) was significantly lower in pregnenolone than in 10 non-depressed volunteers. Cerebrospinal fluid levels are generally believed to accurately reflect levels of various biochemicals in the brain.
Dosage:
10 to 100 mg per day.
| Product Specifications: |
Serving Size: 2 Capsule
Serving Per Container: 45 |
| Amount Per Serving |
| Pregnenolone | 20mg | * |
| *Daily Value not established |
Other Ingredients:
Hydroxypropylmethylcellulose (vegetarian capsule) and microcrystalline cellulose and
Contains no added sugar, starch, salt, wheat, gluten, corn, coloring, dairy products, flavoring or preservatives.
Keep container tightly closed in a cool, dry and dark place. Keep out of reach of children. |
